Monday, March 16, 2009

Homocysteine, cholesterol and ammonia

Remember that this is just a post of my blog, and it evolves, so to see the full story go to: (English) or (Spanish)
My current doc: Josepa Rigau Av Catalunya, 12, 3º, 1ª 43002 Tarragona Spain +34977220358 (I do recommend! hoeopathy and biological medicine, significant improvement)
My previous docs: De Meirleir (, Dra Quintana (CMD), (Lots of medication, antibiotics etc... no significant improvement)

In My latest blood test I seem to have a problem with LDL cholesterol 199, which means that if I do not solve it with diet in 3 months, I will have to take medication for life to prevent arteriosclerosis. This was also confirmed with my genetic study that I will eventualy translate into englesh, which said that I had familiar hipercolesteremia in my genes, and I need to do diet for life the same as sports.

Together with this, I also showed amonia in my blood, high bilirrubine, and high homocysteine.

The findings some studies on homocysteine show several biological conditions that can contribute to conditions such as CFS. In the elderly, some natural processes of aging exist and environmental factors such malnutrition may produce similar patterns to CFS. Inflammatory processes have been implicated in a number of diseases including diabetes and atherosclerosis. The results of these studies also show that CFS has an important inflammatory component as well that could very well lead to those illnesses and others.


-Homocysteinemia can be caused by a genetic defect of methionine.
-Homocysteine can accumulate in blood due to dietary deficiencies of folate and vitamins B12 and B6 or through excessive intake of the amino acid methionine. Homocysteinemia is assumes to occur through different pathways. (Troen)
-Homocysteine impairs the nitric oxide pathway which contributes to endothelial dysfunction. (Stuhlinger)

Regland, B., Andersson, M., Abrahamsson, L., Bagby, J., Dyrehag, L. E., and Gottfries, C. G. (1997). Increased concentrations of homocysteine in the cerebrospinal fluid in patients with fibromyalgia and chronic fatigue syndrome. Scandinavian journal of rheumatology, 26(4):301-307.
Insciences. (2008). Study shows inflammation from chronic fatigue syndrome may be risk factor for other illnesses.
Ventura, E., Durant, R., Jaussent, A., Picot, M. C., Morena, M., Badiou, S., Dupuy, A. M., Jeandel, C., and Cristol, J. P. (2009). Homocysteine and inflammation as main determinants of oxidative stress in the elderly. Free radical biology & medicine, 46(6):737-744.
Stuhlinger, M. C., Tsao, P. S., Her, J.-H., Kimoto, M., Balint, R. F., and Cooke, J. P. (2001). Homocysteine impairs the nitric oxide synthase pathway: Role of asymmetric dimethylarginine. Circulation, 104(21):2569-2575.