Monday, January 18, 2010

There are a good number of scientific markers of abnormalities in this disease. Here are just some of those:

1- H2S metabolite Urine Test
De Meirleir

2- RNase L enzyme test
Dr. Robert Suhadolnik

Mitochondrial Failure
Shara Mhyll

4-Spectroscopic diagnosis of Chronic Fatigue Syndrome by visible and near-infrared spectroscopy in serum samples. Japanese researchers concluded that “Vis-NIR spectroscopy for sera combined with chemometrics analysis could provide a promising tool to objectively diagnose CFS.”
Fatigue Clinical Center in Osaka, Japan

Abnormal brain SPECT & PET scans
The Clinical and Scientific Basis of Myalgic Encephalomyelitis/CFS Dr. Byron Hyde

6-Mitochondrial encephalopathy
Dr. Paul Cheney using Magnetic Resonance Spectroscopy

7-Abnormal capillary flow due to high percentage of flat red blood cells instead of the normal discoid shaped red blood cells
Dr. Les Simpson, rheologist from New Zealand

8-Reduced red blood cell mass (RBC) a critical hematological marker of ME-CIFDS-CFS.
(University of Miami)

9- Low circulating blood volume
Dr. David Bell, Lyndonville, New York

10-Abnormal bicycle ergometry test with gas analysis indicating immediate movement to anaerobic threshold in ME-CFIDS patients
Dr. Paul Cheney, who used this test for his disability reports

12-High percentage of patients with a viral load (HHV-6, EBV, cytomegalovirus) and/or Mycoplasma bacteria
Dr. Ablashi, Dr. Knox, Dr. Carrigan, Dr. Nicholson

13-Cardiac abnormalities due to viral invasion into the heart
Dr. Martin Lerner

14-Disregulated HPA axis
Dr. Mark Demitrack, Dr. Anthony Komaroff

15-Disregulated antiviral pathway
Dr. Suhadolnik

16-Head-up tilt test with haemodynamic instability
Dr. J. E. Naschitz

17-Abnormal T-helper 1/T-helper 2 Function Panel
Dr. Paul Cheney

18-Very low/impaired Natural Killer Cell Function
Dr. Paul Cheney, Dr. Kenny Demeirleir

19-Prolonged vasodilatory effect of acetylcholine on the microvasculature addition to Peripheral Cholinergic illness in ME-CFIDS patients, Gulf War Illness, and illness following Organophosphate Exposure.
(Dr. Vance Spence)

20-Cardiomyopathy, liver failure, pancreatic cancer, brain tumors & renal disease ...reported after 40 years of research in Enteroviral and Toxin Mediated ME-CFIDS and Other Organ Pathologies.
(Dr. John Richardson)

21-Positive testing for Ciguatera Toxin Epitope
Dr. Yoshitsugi Hokama (Research funded by the National CFIDS/M.E. Foundation)

22-Neurally mediated hypotension

23-Abnormal “voyager” RNA (Preliminary studie)
Dr. Paul Cheney

24- 5-HIAA, a metabolite of serotonin, may be present in elevated levels in ME-CFIDS patients
Georgetown University

25- Concentrations of a glucose metabolite in red blood cells

26- Differences in gene expression profiles
Dr. William Reeves in the cfids Chronicle

27- Excess nitric oxide activity

28- Blood hypercoagulability

29- Subclinical adrenal insufficiency
(present in about 2/3's of cases)

30- Reduced body temperature (can be caused by hypoadrenal +/- hypothyroid)

31- Magnesium deficiency