There are a good number of scientific markers of abnormalities in this disease. Here are just some of those:
1- H2S metabolite Urine Test
De Meirleir
2- RNase L enzyme test
Dr. Robert Suhadolnik
3 Mitochondrial Failure
Shara Mhyll
4-Spectroscopic diagnosis of Chronic Fatigue Syndrome by visible and near-infrared spectroscopy in serum samples. Japanese researchers concluded that “Vis-NIR spectroscopy for sera combined with chemometrics analysis could provide a promising tool to objectively diagnose CFS.”
Fatigue Clinical Center in Osaka, Japan
5 Abnormal brain SPECT & PET scans
The Clinical and Scientific Basis of Myalgic Encephalomyelitis/CFS Dr. Byron Hyde
6-Mitochondrial encephalopathy
Dr. Paul Cheney using Magnetic Resonance Spectroscopy
7-Abnormal capillary flow due to high percentage of flat red blood cells instead of the normal discoid shaped red blood cells
Dr. Les Simpson, rheologist from New Zealand
8-Reduced red blood cell mass (RBC) ...is a critical hematological marker of ME-CIFDS-CFS.
(University of Miami)
9- Low circulating blood volume
Dr. David Bell, Lyndonville, New York
10-Abnormal bicycle ergometry test with gas analysis indicating immediate movement to anaerobic threshold in ME-CFIDS patients
Dr. Paul Cheney, who used this test for his disability reports
12-High percentage of patients with a viral load (HHV-6, EBV, cytomegalovirus) and/or Mycoplasma bacteria
Dr. Ablashi, Dr. Knox, Dr. Carrigan, Dr. Nicholson
13-Cardiac abnormalities due to viral invasion into the heart
Dr. Martin Lerner
14-Disregulated HPA axis
Dr. Mark Demitrack, Dr. Anthony Komaroff
15-Disregulated antiviral pathway
Dr. Suhadolnik
16-Head-up tilt test with haemodynamic instability
Dr. J. E. Naschitz
17-Abnormal T-helper 1/T-helper 2 Function Panel
Dr. Paul Cheney
18-Very low/impaired Natural Killer Cell Function
Dr. Paul Cheney, Dr. Kenny Demeirleir
19-Prolonged vasodilatory effect of acetylcholine on the microvasculature ...in addition to Peripheral Cholinergic illness in ME-CFIDS patients, Gulf War Illness, and illness following Organophosphate Exposure.
(Dr. Vance Spence)
20-Cardiomyopathy, liver failure, pancreatic cancer, brain tumors & renal disease ...reported after 40 years of research in Enteroviral and Toxin Mediated ME-CFIDS and Other Organ Pathologies.
(Dr. John Richardson)
21-Positive testing for Ciguatera Toxin Epitope
Dr. Yoshitsugi Hokama (Research funded by the National CFIDS/M.E. Foundation)
22-Neurally mediated hypotension
23-Abnormal “voyager” RNA (Preliminary studie)
Dr. Paul Cheney
24- 5-HIAA, a metabolite of serotonin, may be present in elevated levels in ME-CFIDS patients
Georgetown University
25- Concentrations of a glucose metabolite in red blood cells
26- Differences in gene expression profiles
Dr. William Reeves in the cfids Chronicle
27- Excess nitric oxide activity
28- Blood hypercoagulability
29- Subclinical adrenal insufficiency
(present in about 2/3's of cases)
30- Reduced body temperature (can be caused by hypoadrenal +/- hypothyroid)
31- Magnesium deficiency
1- H2S metabolite Urine Test
De Meirleir
2- RNase L enzyme test
Dr. Robert Suhadolnik
3 Mitochondrial Failure
Shara Mhyll
4-Spectroscopic diagnosis of Chronic Fatigue Syndrome by visible and near-infrared spectroscopy in serum samples. Japanese researchers concluded that “Vis-NIR spectroscopy for sera combined with chemometrics analysis could provide a promising tool to objectively diagnose CFS.”
Fatigue Clinical Center in Osaka, Japan
5 Abnormal brain SPECT & PET scans
The Clinical and Scientific Basis of Myalgic Encephalomyelitis/CFS Dr. Byron Hyde
6-Mitochondrial encephalopathy
Dr. Paul Cheney using Magnetic Resonance Spectroscopy
7-Abnormal capillary flow due to high percentage of flat red blood cells instead of the normal discoid shaped red blood cells
Dr. Les Simpson, rheologist from New Zealand
8-Reduced red blood cell mass (RBC) ...is a critical hematological marker of ME-CIFDS-CFS.
(University of Miami)
9- Low circulating blood volume
Dr. David Bell, Lyndonville, New York
10-Abnormal bicycle ergometry test with gas analysis indicating immediate movement to anaerobic threshold in ME-CFIDS patients
Dr. Paul Cheney, who used this test for his disability reports
12-High percentage of patients with a viral load (HHV-6, EBV, cytomegalovirus) and/or Mycoplasma bacteria
Dr. Ablashi, Dr. Knox, Dr. Carrigan, Dr. Nicholson
13-Cardiac abnormalities due to viral invasion into the heart
Dr. Martin Lerner
14-Disregulated HPA axis
Dr. Mark Demitrack, Dr. Anthony Komaroff
15-Disregulated antiviral pathway
Dr. Suhadolnik
16-Head-up tilt test with haemodynamic instability
Dr. J. E. Naschitz
17-Abnormal T-helper 1/T-helper 2 Function Panel
Dr. Paul Cheney
18-Very low/impaired Natural Killer Cell Function
Dr. Paul Cheney, Dr. Kenny Demeirleir
19-Prolonged vasodilatory effect of acetylcholine on the microvasculature ...in addition to Peripheral Cholinergic illness in ME-CFIDS patients, Gulf War Illness, and illness following Organophosphate Exposure.
(Dr. Vance Spence)
20-Cardiomyopathy, liver failure, pancreatic cancer, brain tumors & renal disease ...reported after 40 years of research in Enteroviral and Toxin Mediated ME-CFIDS and Other Organ Pathologies.
(Dr. John Richardson)
21-Positive testing for Ciguatera Toxin Epitope
Dr. Yoshitsugi Hokama (Research funded by the National CFIDS/M.E. Foundation)
22-Neurally mediated hypotension
23-Abnormal “voyager” RNA (Preliminary studie)
Dr. Paul Cheney
24- 5-HIAA, a metabolite of serotonin, may be present in elevated levels in ME-CFIDS patients
Georgetown University
25- Concentrations of a glucose metabolite in red blood cells
26- Differences in gene expression profiles
Dr. William Reeves in the cfids Chronicle
27- Excess nitric oxide activity
28- Blood hypercoagulability
29- Subclinical adrenal insufficiency
(present in about 2/3's of cases)
30- Reduced body temperature (can be caused by hypoadrenal +/- hypothyroid)
31- Magnesium deficiency
